VGO-0198
QUESTION
The chemotherapy protocol for canine transmissible venereal tumour is vincristine?
OPTIONS
(A) @ 0.025 mg/kg body wt, slow iv once a week for 4 weeks
(B) @ 0.25 mg/kg body wt, slow iv once a week for 4 weeks
(C) @ 0.0025 mg/kg body wt, slow iv once a week for 4 weeks
(D) @ 0.00025 mg/kg body wt, slow iv once only
ANSWER
(A) @ 0.025 mg/kg body wt, slow iv once a week for 4 weeks
EXPLANATION
Vincristine at 0.025 mg/kg intravenously once weekly is a recognized regimen for canine transmissible venereal tumor, making option (A) the appropriate dose and interval. A dose of 0.25 mg/kg is tenfold higher, while 0.0025 and 0.00025 mg/kg are substantially below the stated therapeutic dose. Four weeks may achieve remission in some cases, but the actual course is adjusted to tumor response and hematologic monitoring rather than being universally fixed.
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