VMC-0041
QUESTION
Anaphylaxis is mediated by…?
OPTIONS
(A) Mast cells
(B) IgE
(C) Both of above
(D) None of above
ANSWER
(C) Both of above
EXPLANATION
Anaphylaxis is an immediate type I hypersensitivity reaction in which allergen-specific IgE bound to Fcε receptors on mast cells is cross-linked, causing mast-cell degranulation and mediator release. Thus option C is correct because both mast cells and IgE are essential; either one alone gives an incomplete description.
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