VMC-0002
QUESTION
Hybridomas are result of fusion of?
OPTIONS
(A) Normal antibody producing cells with Myeloma cells
(B) Abnormal antibody producing cells with Myeloma cells
(C) Male reproductive cell with Myeloma cells
(D) Female reproductive cells with Myeloma cells
ANSWER
(A) Normal antibody producing cells with Myeloma cells
EXPLANATION
Hybridomas are produced by fusing normal antibody-producing B lymphocytes with immortal myeloma cells. The B cell supplies antibody specificity, while the myeloma cell provides indefinite proliferative capacity. Option A is therefore correct; abnormal antibody-producing cells and male or female reproductive cells are not the cellular components used to make antibody-secreting hybridomas.