VPT-0090
QUESTION
The determinants of bioavailability are?
OPTIONS
(A) Rheological parameters of blood
(B) Amount of a substance obtained oral
(C) Extent of absorption and hepatic first-pass effect
(D) Glomerular filtration rate
ANSWER
(C) Extent of absorption and hepatic first-pass effect
EXPLANATION
Bioavailability is determined mainly by the extent of absorption and the hepatic first-pass effect, which together determine how much unchanged drug reaches systemic circulation. Rheological blood parameters and glomerular filtration rate do not define oral bioavailability, and the amount obtained orally alone is incomplete.
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Veterinary Pharmacology and Toxicology · 167 Questions
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