VPT-0111
QUESTION
If the journey of drug from its extravascular site of administration across various lipoidal membrane barriers is to be illustrated, in biological fluids, which of the following will be correct order??
OPTIONS
(A) Interstitial fluid – Plasma – Interstitial fluid – Intracellular fluid – Intraorganellar fluid
(B) Plasma – Interstitial fluid – Intraorganellar fluid – Interstitial fluid – Intracellular fluid
(C) Intracellular fluid – Interstitial fluid – Plasma – Intraorganellar fluid – Interstitial fluid
(D) Plasma – Interstitial fluid – Intracellular fluid – Interstitial fluid – Intraorganellar fluid
ANSWER
(A) Interstitial fluid – Plasma – Interstitial fluid – Intracellular fluid – Intraorganellar fluid
EXPLANATION
After extravascular administration, drug generally moves from the interstitial fluid at the administration site into plasma, then into other interstitial fluid, intracellular fluid, and finally intraorganellar fluid. This sequence is represented by option A; the other sequences place the fluid compartments in an incorrect order.