VPT-0050
QUESTION
Mannitol is contra indicated in dogs suffering from congestive heart failure because it?
OPTIONS
(A) Increases blood volume and precipitates pulmonary edema
(B) Causes hypovolemia with excess excretion of Na+ , K+ , and Cl- ions
(C) Both Increases blood volume and precipitates pulmonary edema & causes hypovolemia with excess excretion of Na+ , K+ and Cl- ions
(D) None of the above
ANSWER
(C) Both Increases blood volume and precipitates pulmonary edema & causes hypovolemia with excess excretion of Na+ , K+ and Cl- ions
EXPLANATION
Mannitol initially expands plasma volume by drawing water into the vascular compartment, which can worsen pulmonary edema in congestive heart failure; its osmotic diuresis also promotes electrolyte loss. Thus both effects described in option C explain the contraindication, while either effect alone is incomplete.
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Veterinary Pharmacology and Toxicology · 167 Questions