VPT-0030
QUESTION
The following diuretic inhibit water and solute reabsorption by increasing osmolarity of tubular fluid at proximal tubules?
OPTIONS
(A) Mannitol
(B) Furosemide
(C) Spironolactone
(D) Acetazolamide
ANSWER
(A) Mannitol
EXPLANATION
Mannitol is freely filtered and remains in the tubular lumen, increasing osmolarity and inhibiting water and solute reabsorption, especially in the proximal tubule. Furosemide acts mainly at the Na+-K+-2Cl− cotransporter, spironolactone antagonizes aldosterone, and acetazolamide inhibits carbonic anhydrase.
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