Heat labile E. coli is activated by enzyme?

VMC-0022

QUESTION

Heat labile E. coli is activated by enzyme?

OPTIONS

(A) Glutamate cyclase
(B) Adenylate cyclase
(C) Adeno mutase
(D) Sorbitol dehydrogenase

ANSWER

(B) Adenylate cyclase

EXPLANATION

Heat-labile enterotoxin of enterotoxigenic E. coli activates adenylate cyclase through Gs protein, increasing intracellular cyclic AMP and promoting chloride and water secretion. Thus option B is correct; glutamate cyclase, adeno mutase, and sorbitol dehydrogenase are not the enzyme responsible for this signaling pathway.

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