VPY-0045
QUESTION
Which among the following triggers directly the movement of GLUT-4 glucose transporters to the plasma membrane?
OPTIONS
(A) Cortisol
(B) Epinephrine
(C) Insulin
(D) Glucagon
ANSWER
(C) Insulin
EXPLANATION
Insulin is the correct option because insulin stimulates translocation of GLUT4-containing vesicles to the plasma membrane in skeletal muscle and adipose tissue, increasing glucose uptake. Cortisol, epinephrine and glucagon generally oppose insulin's glucose-lowering actions or act through different metabolic pathways and do not directly trigger GLUT4 translocation.