VMD-0066
QUESTION
Intrahepatic cholestasis is indicated by elevated serum levels of which of the following?
OPTIONS
(A) Glutamate dehydrogenase
(B) ALT
(C) Sorbitol dehydrogenase
(D) GGT
ANSWER
(D) GGT
EXPLANATION
Gamma-glutamyl transferase, or GGT, rises prominently with cholestasis and biliary epithelial injury, making it a useful marker of intrahepatic or extrahepatic bile-flow obstruction. GLDH and sorbitol dehydrogenase primarily reflect hepatocellular injury, while ALT has limited liver specificity in many large-animal species.
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