VPP-0042
QUESTION
Estimation of MMA in urine helps to detect?
OPTIONS
(A) Cu deficiency
(B) Zn deficiency
(C) Co deficiency
(D) Mn deficiency
ANSWER
(C) Co deficiency
EXPLANATION
Methylmalonic acid (MMA) accumulates when vitamin B12-dependent metabolism is impaired and is therefore used as an indicator of functional cobalamin deficiency. In ruminants, cobalt deficiency can lead to vitamin B12 deficiency because rumen microbes require cobalt to synthesize cobalamin. Copper, zinc, and manganese deficiencies do not characteristically cause increased urinary MMA. Therefore, option C is correct.