VPY-0056
QUESTION
One of the reasons for ketone body formation is?
OPTIONS
(A) Drop in OAA
(B) Excess glucose metabolism
(C) Excess blood glucose
(D) Increase in Glucagon
ANSWER
(A) Drop in OAA
EXPLANATION
Drop in OAA is the correct option because a reduction in oxaloacetate limits entry of acetyl-CoA into the TCA cycle, causing acetyl-CoA to accumulate and be diverted toward ketone-body synthesis, particularly during fasting or carbohydrate deficiency. Excess glucose metabolism and excess blood glucose generally suppress ketogenesis, while increased glucagon promotes ketogenesis indirectly but is not the specific metabolic reason given here.