VPY-0046
QUESTION
While degradation which of the following amino acid does not get converted to α-ketoglutarate?
OPTIONS
(A) Glutamine
(B) Proline
(C) Arginine
(D) Threonine
ANSWER
(D) Threonine
EXPLANATION
Threonine is the correct option because threonine is degraded through pathways that do not primarily yield α-ketoglutarate as its carbon skeleton's principal endpoint. Glutamine is converted to glutamate and then α-ketoglutarate, proline can be converted to glutamate and α-ketoglutarate, and arginine can also enter pathways leading toward glutamate/α-ketoglutarate.